ABSTRACT The novel drug delivery system is creating a new interest in development of drug deliveries. Vesicular drug delivery system is also a part of this novel drug delivery system which is designed according to the recent demands of treatment of drug in systemic circulation, definite dosing interval. Transferosomes are ultradeformable vesicles possessing an aqueous core surrounded by the complex lipid bilayer used to enhance skin permeation. Interdependency of local composition and shape of the bilayer makes the vesicle both self-regulating and self-optimizing. The present investigation was majorly aimed to develop transferosomes of tizanidine by reverse phase evaporation method. Various process variables were studied to optimize the formulation including lecithin: cholesterol: surfactant and different solvent (methanol and chloroform). The drug content varies from 78.36 – 89.47%. The percent entrapment efficiency was found between 65.12 – 82.03%. The transferosomes were characterized by SEM, FTIR and DSC studies. The physical stability was tested out for all formulations for the period of three months and in-vitro permeation studies was performed using saline phosphate buffer showed 16.39 μg/cm2/hr and amount of tizanidine deposited in the skin was maximum 67.69 μg respectively. The data obtained from the study results evidenced that transferosomes are promising drug delivery carriers for the many potential drugs and was proved the potent muscle relaxant tizanidine. Keywords: Surfactant, Lecithin, Permeation, Flux, Lipid bilayer, Reverse phase evaporation.

ABSTRACT Ranitidine hydrochloride (RHCl) is a histamine H2-receptor antagonist. It is widely prescribed in active duodenal ulcers, gastric ulcers, Zollinger-Ellison syndrome, gastro-esophageal reflux disease, and erosive esophagitis. Floating tablets containing 336mg of Ranitidine hydrochloride could be prepared by wet -granulation technique employing Okra gum of different grades as natural polymer and release retardant, Ethyl cellulose, Sodium CMC as floating enhancer and sodium bicarbonate and citric acid as gas generating agent. The evaluation results for in-vitro drug release showed that Okra gum was able to retard the drug release more than 12 hours. All the floating tablets prepared contained ranitidine hydrochloride within 100 ± 5% of the labelled claim. As such the prepared floating tablets were of good quality with regard to drug content , angle of repose, bulk density and tapped density and. In the in-vitro buoyancy study varieties were observed in the floating lag time and floating time. The dissolution data of tablets F1 to F9 was fitted to zero order, first order, Korsmeyer and Peppas and Higuchi models. The results of correlation coefficient (R2) were used to select the most appropriate model. The release profiles of formulations F7 fitted best to zero order model. Keywords: Controlled systems, Floating systems, Natural polymer, Semi-Synthetic polymers.

ABSTRACT Chemotherapy –induced nausea and vomiting (CINV), also known by the term emesis, is one of the most common and dreaded side effects following cancer treatment, and can strongly impact the quality of day –to-day living of cancer patients. Many Chemotherapeutic agents are associated with significant nausea and vomiting which represent a challenge to effective therapy. The active ingredients present in Zinper softgels are terpenes and oleoresin. The major identified components from terpenes are gingerol and shogaols. Zinper softgels has staring potential as anti-tumor, anti-oxidant, anti inflammatory, anti-microbial, anti-emetic effect, Anti-angiogenesis, anti-nausea and an effective adjuvant treatment for chemotherapy-induced nausea and vomiting.The effectiveness of Zinper softgels in preventing or suppressing cancer growth has been examined in a variety of cancer types, including lymphoma, hepatoma, colorectal cancer, breast cancer, skin cancer, liver cancer, and bladder cancer. This article reviews the current available scientific literature regarding the effect of Zinper softgels as A Natural Nutrient to Promote Healthy GI peristalsis in cancer patients. Keywords: ZINPER Soft Gels, Healthy GI peristalsis.

ABSTRACT Methanolic extract of Gracilaria corticata J.Ag. was subjected to paw edema anti-inflammatory test. The extract was injected into Wistar albino rats and the paw volume was measured in mm by Mercury Displacement method. Results revealed that the methanolic extract had good anti-inflammatory effects in the carageenan induced paw edema compared to those of control. Maximum inhibition of 0.35mm was found in the fourth hour after carageenen injection in Gracilaria corticata J.Ag. at 200mg/kg methanol extract. Similarly 0.4mm of inhibition was also noticed in 400mg/kg methanolic extract of Gracilaria corticata J.Ag. after the fourth hour. The anti-inflammatory activity had its peak at the dose of 400mg/kg as compared to 200mg/kg methanolic extract. Keywords: Red Seaweed, Anti-inflammatory, Gracilaria corticata, Methanolic extract, Wistar rats.

Two new, simple, accurate and sensitive UV Spectrophotometric methods have been developed and subsequently validated for the simultaneous estimation of Lopinavir (LOPI) and Ritonavir (RIT) in a fixed dose combination. Lopinavir and Ritonavir have an absorption maxima at 258nm and 245nm respectively. The first method is based upon the simultaneous equation and second upon the determination of Q value. The simultaneous equation method is based upon the measurements of ratios of absorptivity and absorbance, of both the components at their absorption maxima. The method of Q analysis is based on the measurement of ratios of absorptivity and absorbance, of both components at two selected wavelengths; one is an isoabsorptive point i.e. 237 nm and other being the wavelength maxima of any of the two components, say 𝞴max of Lopinavir i.e. 258 nm. Lopinavir shows linearity over the concentration range of 10-30μg/mL and whereas Ritonavir at 2-10μg/mL at their respective absorption maxima and at isoabsorptive point. The assay and recovery studies from fixed dose combination as liquid fill formulations for soft gels are indicative of accuracy of the proposed methods. The developed methods were validated in accordance to International Conference on Harmonization (ICH) guidelines for linearity, range, accuracy and precision. Keywords: UV Spectrophotometry, Lopinavir, Ritonavir, Anti-retroviral, Absorption Ratio.

The present review focused on In vitro methods of antioxidant activity and many medicinal Indian herbs that have great antioxidant potential. This review covers medicinal species from a variety of countries (Africa, Algeria, The United States of America, Australia, Brazil, Bulgaria, China, India, Iran, Italy, Japan, Malaysia, Poland, Portugal, Thailand and Turkey, The purpose of this review is to survey the antioxidant capacity and to evaluate potential sources of natural antioxidants for food and medicinal purposes. According to a phytochemical database USDA 2003 the number of different antioxidants in some plants can reach up to 40 (soybean 42, tea 36, fennel 35, oregano 34, onion 32, thyme 32, etc). In this database, plants with the highest contents of antioxidants are walnut, betel nut, guava, coconut, and other less known plants. A list of some known substances with antioxidant activity in some very common spices is reported. Keywords: Antioxidant, Therapeutic Effects, Medicinal plants.