For producing systemic effect, administration of drug through oral route is mostly preferred. But due to the release of
drug at upper GI tract and lower accessibility of drug at lower GI tract, oral route sometimes becomes less efficient for drug
administration. To surpass this difficulty, colon specific drug delivery system has been analyzed for the last two decades. The
colon is a region where both local and systemic delivery of drugs can take place. CDDS are desirable for the treatment of a range
of local diseases such as ulcerative colitis, crohn’s disease, inflammatory bowel disease, colonic cancer etc. In addition, the colon
can be a potential site for systemic absorption of several drugs to treat non-colonic condition as well. In order to gain effective
therapeutic outcomes, it is vital that the designed delivery system specifically targets the drug into the colon in a predictable and
reproducible manner. This review presents a systematic discussion of various conventional as well as relatively newer formulation
technologies currently being utilized for the development of CDDS