Herbal medicines are still the mainstay of about 75-80% of the world's population, mainly in developing countries, for primary health care because of better cultural acceptability, better compatibility with human body sanda lesser side effects. Herbal medicines consist of plants or it's part to treat injuries, diseases or illnesses and are used to prevent and treat diseases and alimentary or to promote health and healing. It's a drug or preparation made from a plant or plants used for any such purpose. Herbal medicines are the oldest form of health care known to mankind. Gel formulations prepared with Xanthan gum and flax seed extract showed good homogeneity, no skin irritation, and good stability and anti hyperpigmentation activity. However the xanthan gum based gel proved to be the formula of choice, since it showed the highest percentage of extrudability, good spreadability and theological properties. When the combination of beetroot juice,liquorice extract and flax seed showed good anti hyperpigmentation activity

Microfluidics is a promising field in the future of medicine and technology. It requires a minute amount of samples or reagents. This review article describes a better understanding of the emerging concept of Microfluidics and its versatility in the medical field. Organ on-chip, disease detection, drug discovery, detection of blood cells, are the main areas in which the microfluidics concept is utilized effectively. The future road map of microfluidics is also gifted in terms of new advances in technology, reliability, high resolution, faster results, etc

The aim of present study was to formulate the colon targeted matrix mini-tablet of Sulfasalazine and to evaluate the formulation for various parameter to release the active ingredient after predetermine time in a predetermine location with better pharmaceutical and therapeutic properties. Sulfasalazine has anti-inflammatory, immunosuppressive, and antibiotic actions, the pharmacological effects of which are mainly attributed to its breakdown products sulfapyridine and 5-aminosalicylic acid. Sulfasalazine is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. It is considered by some to be a first-line treatment in rheumatoid arthritis. Sulfasalazine is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum) and also to maintain improvement of ulcerative colitis symptoms. It has been developed as colon-specific delivery systems for the treatment of inflammatory bowel disease (IBD).

Cyclophosphamide (CP), usually known as cytophosphane, is a chemotherapy medication that is also used to suppress the immune system. It has a relatively quick first pass metabolism, a short elimination half-life, and a poor absorption, which results in testosterone decrease only when supplied constantly. Thus, in the current investigation, an attempt was made to include a suitable polymer into nanoparticles carrying the medication. Cyclophosphomide Nanoparticles were produced using Ionic Gelation Method combining acetic acid and gelatin in varied quantities. Various evaluation methods including the entrapment efficiency, SEM analysis, invitro drug release were done to verify the produced nanoparticles were of excellent quality. The generated nanoparticles appear to have a larger potential for drug release than ordinary polymer materials. Due to the manipulation of drug release in in vitro drug release testing, extensive in vivo estimation and drug release study are necessary to build a correct relationship between in vitro and in vivo investigations

The moisture content present in human skin makes it look young and the use of moisturizer results in fastening the moisture with a surface film of oil. Currently acne and wrinkles are most commonly seen skin problem among the youth. The aim of the study was to prepare and evaluate herbal based moisturized cream for the treatment of acne and wrinkles with additional benefit of moisturize the skin. Totally six formulations were developed with varying concentration of excipients and herbals. The prepared products were evaluated for appearance, colour, pH, viscosity, spreadability, rheological study, and stability Formulations F3 showed good spreadability. In conclusion, F3 formulation found to be best quality among the other prepared cosmetic formulations

SE system is isotropic blend of drug, oil, surfactants and/or co solvents forming O/W emulsion in GI fluids, with mild agitation by GIT. Formed o/w emulsions have more stability in thermodynamic way as small amount of dispersed oil, fine sizes of droplets; more interface area improves activity & decreases drug-gut wall irritation. Therefore, SEDDS is competent system for BCS class II & IV drugs. Pre formulation studies like appearance, melting point, pH and spectroscopy of ritonavir showed that sample was pure. Calibration curve of Ritonavir was generated in different mediums, which showed that drug followed beer lamberts law. Saturated solubility study of Ritonavir in different vehicles showed that drug posses’ high solubility in oleic acid, Tween 80 and Capmul MCM. From pseudo ternary phase diagram, highest micro emulsion zone found was at Smix ratio (1:3). From pseudo ternary diagram, quantitative selection of vehicles was done and liquid SMEDDS formulations of Ritonavir were prepared (S1to S5) by varying concentration of oil and Smix. The optimized SMEDDS S2 contained Oleic acid (28.8 %W/W), TWEEN 80 (16.8 %W/W) and CAPMUL MCM (50.4 % W/W). The SMEDDS S2 showed high negative zeta potential near to range, homogenous globule distribution (from PDI), smaller droplet size, high % T and % drug content in comparison to S1 and S3. S2 showed drug release of 99.77 % whereas pure drug showed 34.99 % at 30 min in Ph 1.2. S2 showed drug release of 99.76 % whereas pure drug showed 56.18 % at 30 min in pH 7.0 buffer with SLS, S2 showed drug release of 99.7 % whereas pure drug showed 35.02% at 30 min in pH 7.0 buffer without SLS, which indicate drastic improvement in drug release from liquid SMEDDS S2 in comparison to pure drug and even pure drug showed effect of SLS in pH 7.0 buffer on release of drug, while liquid SMEDDS didn’t showed effect of pH and SLS on release of drug. S2 showed high % drug release in comparison to S1 and S3

The aim of current research to formulate tooth gel utilizing leaf extract of Aloe Vera.The magical properties of Aloe Vera have been known to worldwide since time immemorial .It has inherent properties which help in enhancing health and wellbeing of an individual in most natural way possible .Its medicinal properties like antiviral ,antibacterial and wound healing capacity has led to curiosity of using Aloe Vera in treatment of various dental problems .Tooth gel from the Aloe Vera leaf extract in various concentrations are prepared (0%,5%,7.5%,10%,15%).The formulated Aloe Vera tooth gel evaluated by several physical parameters. From the evaluation ,the tooth gel of appropriate concentration of Aloe Vera leaf extract are identified .The outcome from this research evidently signified that the natural plant Aloe Vera using to formulate tooth gel may be a new approach to formulate tooth gel economically and minimum side effect