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Canagliflozin is an orally well-administered drug. It is under the type of sodium-glucose co-transporter- 2 (SGLT-2) inhibitor
used in the treatment of type-II diabetes patient. By inhibiting the transporter protein SGLT-2 in the kidneys, canagliflozin
reduces renal glucose reabsorption, thereby increasing urinary glucose excretion and reducing blood glucose levels. Canagliflozin
is estimated by RP-HPLC, RP-LC, UV-Spectrophotometer, UPLC, HPTLC, LC-MS, FT-IR methods, spectoflurimetry. There are
plenty of articles which have already been published describing analytical method and method validation for the same. In present
to review account, the disclosed analytical methods are outlined for the establishment of canagliflozin in its Pharmaceutical
preparations and biological matrices. Most frequently used techniques such as spectrometric and liquid chromatography method
for canagliflozin alone and in combination include parameters like ? max, solvent, matrix etc. and HPLC method for canagliflozin
alone and in combination including parameters like matrix, stationary phase, mobile phase, composition, detection, wavelength
etc. HPTLC methods including parameters like stationary phase, mobile phase combination, RF etc. This review also provides
detailed information on separation condition for canagliflozin alone, in the presence combination with other drugs and in presence
of its degradation products
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The purpose of writing this review was to investigate, compile and present the recent as well as past literatures in more
concise way with special focus on approaches which are currently utilized in the prolongation of gastric residence time. One
novel approach in this area is Gastro Retentive Drug Delivery System (GRDDSs). GRDDSs can improve the controlled delivery
of drugs that have an absorption window by continuously releasing the drug for a prolonged period of time before it reaches its
absorption site. These includes floating system, swelling and expanding system, bio/ mucoadhesive system, high density system
and other delayed gastric emptying devices. The present review addresses briefly about the, factors controlling gastric retention,
advantages, Disadvantages and applications of gastro retentive drug delivery systems, commonly used drug in formulation of
GRDDS, Gastro retentive products available in the market, types of GRDDS
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